742 Augmentation of HGF signaling: Potential for enhancing hair follicle neogenesis and development in bioengineered skin
نویسندگان
چکیده
منابع مشابه
Wnt Signaling in Hair Follicle Development
HF is a mini-organ formed with mesenchymal-epithelial interaction (Schmidt-Ullrich & Paus, 2005). HF development and cycle are depended on signaling between its epidermal and dermal components. Especially, dermal organizing center, DP, is both chemical and physical niche for epithelial stem cells. DP plays an important role in HF induction and cycling by controlling self-renewal and differentia...
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15 صفحه اولCharacterization of Hair Follicle Development in Engineered Skin Substitutes
Generation of skin appendages in engineered skin substitutes has been limited by lack of trichogenic potency in cultured postnatal cells. To investigate the feasibility and the limitation of hair regeneration, engineered skin substitutes were prepared with chimeric populations of cultured human keratinocytes from neonatal foreskins and cultured murine dermal papilla cells from adult GFP transge...
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Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and late stage differentiation, Notch signaling determines stem cell fate while BMP is involved in cellular differentiation. The Wnt pathway is conside...
متن کاملPrinciples and mechanisms of regeneration in the mouse model for wound‐induced hair follicle neogenesis
Wound induced hair follicle neogenesis (WIHN) describes a regenerative phenomenon in adult mammalian skin, wherein fully functional hair follicles regenerate de novo in the center of large excisional wounds. Originally described in rats, rabbits, sheep, and humans in 1940-60, the WIHN phenomenon was reinvestigated in mice only recently. The process of de novo hair regeneration largely duplicate...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.02.785